3058-01-3
3058-01-3
Chemical Structure
3-Methyladipic acid
- CAS No.: 3058-01-3
- Formula:C7H12O4
- Molecular Weight:160.17
IUPAC Name: 3-methylhexanedioic acid
InChIKey: SYEOWUNSTUDKGM-UHFFFAOYSA-N
SMILES: O=C(O)CC(C)CCC(O)=O
Biological Activity: 3-Methyladipic acid is the final metabolite produced by the degradation of phytanic acid via the ω-oxidation pathway when α-oxidation is impaired, and it is mainly excreted in urine. 3-Methyladipic acid is also present at low levels in healthy individuals, but is significantly elevated in Refsum disease, and can serve as a marker of ω-oxidation activity[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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3-Methyladipic acid | 98.0% | 3-Methyladipic acid is the final metabolite produced by the degradation of phytanic acid via the ω-oxidation pathway when α-oxidation is impaired, and it is mainly excreted in urine. 3-Methyladipic acid is also present at low levels in healthy individuals, but is significantly elevated in Refsum disease, and can serve as a marker of ω-oxidation activity. | ||||||||||||||||||||
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3-Methyladipic acid (Standard) | ≥98% | 3-Methyladipic acid (Standard) is the analytical standard of 3-Methyladipic acid (HY-113277). This product is intended for research and analytical applications. 3-Methyladipic acid is the final metabolite produced by the degradation of phytanic acid via the ω-oxidation pathway when α-oxidation is impaired, and it is mainly excreted in urine. 3-Methyladipic acid is also present at low levels in healthy individuals, but is significantly elevated in Refsum disease, and can serve as a marker of ω-oxidation activity. | ||||||||||||||||||||
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3-Methylglutaric acid (Standard) | ≥98% | 3-Methylglutaric acid (Standard) is the analytical standard of 3-Methylglutaric acid (HY-113410). This product is intended for research and analytical applications. 3-Methylglutaric acid is a non-selective inhibitor of mitochondrial function and Na+, K+-ATPase, with an inhibition rate of 30% on rat cortical synaptosomal Na+, K+-ATPase. 3-Methylglutaric acid can induce reactive oxygen species (ROS) generation, thereby causing oxidative damage and inhibiting mitochondrial redox potential and ion pump function of cell membranes. 3-Methylglutaric acid can be used to study the neuropathological mechanisms of metabolic diseases and the role of oxidative stress-mediated neuronal damage in neurodegeneration. | ||||||||||||||||||||
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3-Hydroxysuberic acid | 3-Hydroxysuberic acid is a Suberic acid (HY-W015300) metabolite with serum downregulation in obese individuals. 3-Hydroxysuberic acid associates with colorectal and lung cancer. 3-Hydroxysuberic acid can be used for the research of colorectal cancer and lung cancer. | |||||||||||||||||||||
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Succinic acid | 98.10% | Succinic acid is an anti-anxiety agent with oral activity. Disodium succinate is the salt form of Succinic acid. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid is an important platform chemical. Succinic acid can be used as surfactant, additive, ion chelating agent, flavoring agent and other applications in chemical, pharmaceutical and food fields. | ||||||||||||||||||||
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Succinic acid-13C4 | 99.7% | Succinic acid-13C4 is the 13C labeled Succinic acid. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries. | ||||||||||||||||||||
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Succinic acid-13C2 | 99.0% | Butanedioic acid-13C2 is the 13C labeled Succinic acid. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries. | ||||||||||||||||||||
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Succinic acid-13C2 | Succinic acid-13C2 is the 13C labeled Succinic acid. Succinic acid is a potent and orally active anxiolytic agent. Succinic acid is an intermediate product of the tricarboxylic acid cycle. Succinic acid can be used as a precursor of many industrially important chemicals in food, chemical and pharmaceutical industries. | |||||||||||||||||||||
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Glutaric acid (Standard) | 98.78% | Glutaric acid (Standard) is the analytical standard of Glutaric acid. This product is intended for research and analytical applications. Glutaric acid, C5 dicarboxylic acid, is an intermediate during the catabolic pathways of lysine and tryptophan. Glutaric acid affects pericyte contractility and migration. Glutaric acid is an indicator of glutaric aciduria type I. In Vitro: Glutaric acid (GA) at concentrations of 1 and 2 mM is able to reduce TRAP measurement by up to 28% in a dose-dependent manner (β=0.77; P<0.001). Furthermore, a significantly inverse correlation is also verified between chemiluminescence and TRAP (β=0.81; P<0.001). Glutaric acid does not alter the activities of Cat and SOD, but strongly inhibits (up to 46%) the activity of GPx even at the lower concentration used (0.5 mM). It is observed that the metabolite inhibits this activity in a dose-dependent manner at concentrations as low as 0.05 mM. | ||||||||||||||||||||
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2-Methylsuccinic acid | 98.0% | 2-Methylsuccinic acid is a normal metabolite in human fluids and the main biochemical measurable features in ethylmalonic encephalopathy. | ||||||||||||||||||||
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2-Methylpentanedioic acid | 98.0% | 2-Methylpentanedioic acid is a metabolite of succinic acid, a citric acid cycle intermediate. | ||||||||||||||||||||
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3-Isobutylglutaric acid (Standard) | ≥98% | 3-Isobutylglutaric acid (Standard) is the analytical standard of 3-Isobutylglutaric acid. This product is intended for research and analytical applications. | ||||||||||||||||||||
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References
- [1]. Niwa T, et al. Pattern of aliphatic dicarboxylic acids in uremic serum including a new organic acid, 2,4-dimethyladipic acid. Clinica chimica acta; international journal of clinical chemistry. 1979 Nov 15;99(1):71-83.
- [2]. Wierzbicki AS, et al. Refsum's disease: a peroxisomal disorder affecting phytanic acid alpha-oxidation. Journal of neurochemistry. 2002 Mar;80(5):727-35. [Content Brief]
