3058084-21-9
3058084-21-9
Chemical Structure
Autotaxin-IN-8
- CAS No.: 3058084-21-9
- Formula:C21H20ClN9O
- Molecular Weight:449.90
InChIKey: QHTLDYKMOKMUML-VQFNDLOPSA-N
SMILES: ClC1=CC=C(C=C1)CCNC2=NC=C(C3=NN=C(N4C[C@@]5([H])[C@H](C6=CN=NN6)[C@@]5([H])C4)O3)C=N2
Biological Activity: Autotaxin-IN-8 (Compound 14E) is an orally active Autotaxin inhibitor with an IC50 of 14.2 nM against hAutotaxin. Autotaxin-IN-8 inhibits Autotaxin activity, MAPK activation, LPAR1 and p-ERK1/2. Autotaxin-IN-8 reduces the phosphorylation levels of JNK and p38. Autotaxin-IN-8 decreases collagen deposition in a mouse model of pulmonary fibrosis. Autotaxin-IN-8 can be used in research related to pulmonary fibrosis[1].
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Autotaxin-IN-8 | Autotaxin-IN-8 (Compound 14E) is an orally active Autotaxin inhibitor with an IC50 of 14.2 nM against hAutotaxin. Autotaxin-IN-8 inhibits Autotaxin activity, MAPK activation, LPAR1 and p-ERK1/2. Autotaxin-IN-8 reduces the phosphorylation levels of JNK and p38. Autotaxin-IN-8 decreases collagen deposition in a mouse model of pulmonary fibrosis. Autotaxin-IN-8 can be used in research related to pulmonary fibrosis. | |||||||||||||||||||||
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