305834-79-1
305834-79-1
Chemical Structure
SC79
- CAS No.: 305834-79-1
- Formula:C17H17ClN2O5
- Molecular Weight:364.78
IUPAC Name: ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
InChIKey: DXVKFBGVVRSOLI-UHFFFAOYSA-N
SMILES: O=C(OCC)C(C#N)C1C(C(OCC)=O)=C(N)OC2=CC=C(Cl)C=C12
Biological Activity: SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt[1][2][3].
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SC79 | 98.0% | SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. | ||||||||||||||||||||
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SC79 (Standard) | ≥98% | SC79 (Standard) is the analytical standard of SC79 (HY-18749). This product is intended for research and analytical applications. SC79, a unique specific and BBB permeable Akt activator, activates Akt in the cytosol and inhibits Akt membrane translocation. SC79 specifically binds to the PH domain of Akt. | ||||||||||||||||||||
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References
- [1]. Jo H, et al. Small molecule-induced cytosolic activation of protein kinase Akt rescues ischemia-elicited neuronal death. Proc Natl Acad Sci U S A. 2012 Jun 26;109(26):10581-10586. [Content Brief]
- [2]. So EY, et al. BRAT1 deficiency causes increased glucose metabolism and mitochondrial malfunction. BMC Cancer. 2014 Jul 29;14:548 [Content Brief]
- [3]. Liu X, et al. Activation of Akt by SC79 decreased cerebral infarct in early cerebral ischemia-reperfusion despite increased BBB disruption. Neurosci Lett. 2018 Aug 10;681:78-82. [Content Brief]
