3058842-90-0
3058842-90-0
Chemical Structure
STING agonist-50
- CAS No.: 3058842-90-0
- Formula:C20H14ClN3O4
- Molecular Weight:395.80
InChIKey: DFCBLRBVXHINMR-UHFFFAOYSA-N
SMILES: O=C(C1=C(OC(CN2CC3=CC=CN(N=C4)C3=C4C2=O)=C5Cl)C5=CC(C)=C1)O
Biological Activity: STING agonist-50 is an orally active STING agonist with an IC50 of 3.457 μM. STING agonist-50 activates the STING signaling pathway and promotes the phosphorylation of downstream TBK1 and IRF3. STING agonist-50 induces the expression of IFN-β, CXCL10 and IL-6. STING agonist-50 inhibits tumor growth in syngeneic mouse models. STING agonist-50 can be used for the research of colorectal cancer[1].
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STING agonist-50 | STING agonist-50 is an orally active STING agonist with an IC50 of 3.457 μM. STING agonist-50 activates the STING signaling pathway and promotes the phosphorylation of downstream TBK1 and IRF3. STING agonist-50 induces the expression of IFN-β, CXCL10 and IL-6. STING agonist-50 inhibits tumor growth in syngeneic mouse models. STING agonist-50 can be used for the research of colorectal cancer. | |||||||||||||||||||||
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