3059172-54-9
Chemical Structure
WRN-IN-26
- CAS No.: 3059172-54-9
- Formula:C28H27F3N2O5S
- Molecular Weight:560.58
InChIKey: UXNMESUQCWSRPN-FQRUVTKNSA-N
SMILES: O=C(N([C@H]1CS(=O)(C=C1)=O)CC2=CC=NC(C(C)(O)C)=C2)[C@@H](C3=CC=C(C4=CC=C(F)C(F)=C4)C=C3F)OC
Biological Activity: WRN-IN-26 is an orally active Werner syndrome helicase (WRN) inhibitor with a human Ki value of 58.7 μM and an IC50 value of 0.026 μM. WRN-IN-26 selectively targets the cysteine residues of WRN. WRN-IN-26 induces the expression of p21 protein in MSI-H tumor cells. WRN-IN-26 inhibits the growth of MSI-H tumor cells and exhibits potent in vivo efficacy in MSI-H xenograft tumor models. WRN-IN-26 can be used for the research of microsatellite instability-high (MSI-H) cancers[1].
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WRN-IN-26 | WRN-IN-26 is an orally active Werner syndrome helicase (WRN) inhibitor with a human Ki value of 58.7 μM and an IC50 value of 0.026 μM. WRN-IN-26 selectively targets the cysteine residues of WRN. WRN-IN-26 induces the expression of p21 protein in MSI-H tumor cells. WRN-IN-26 inhibits the growth of MSI-H tumor cells and exhibits potent in vivo efficacy in MSI-H xenograft tumor models. WRN-IN-26 can be used for the research of microsatellite instability-high (MSI-H) cancers. | |||||||||||||||||||||
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