3059216-68-8
3059216-68-8
Chemical Structure
OPA-S-S-alkyne
- CAS No.: 3059216-68-8
- Formula:C19H22N2O4S2
- Molecular Weight:406.52
InChIKey: XASRUOIPZKSSSH-UHFFFAOYSA-N
SMILES: O=CC1=CC=C(C=C1C=O)CCNC(CCSSCCC(NCC#C)=O)=O
Biological Activity: OPA-S-S-alkyne is a cell surface protein-selective labeling agent. OPA-S-S-alkyne selectively labels hyper-reactive extracellular lysines including ROR2 K382 and ENG K285, blocks ENG-BMP9 interaction, and labels purified human serum albumin with minimal bias. OPA-S-S-alkyne can be used for the research of hematologic and influenza A virus infection[1][2][3].
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OPA-S-S-alkyne | OPA-S-S-alkyne is a cell surface protein-selective labeling agent. OPA-S-S-alkyne selectively labels hyper-reactive extracellular lysines including ROR2 K382 and ENG K285, blocks ENG-BMP9 interaction, and labels purified human serum albumin with minimal bias. OPA-S-S-alkyne can be used for the research of hematologic and influenza A virus infection. | |||||||||||||||||||||
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References
- [1]. Wang T, et al. A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. [Content Brief]
- [2]. Ma S, et al. Living Cell Surfacome Lysine Footprinting (LiFT) Captures Virus-Induced Conformational Dynamics and Uncovers Influenza A Virus Host Factors. J Am Chem Soc. 2026;148(2):2260-2272. [Content Brief]
- [3]. Zheng Z, et al. Covalent Modification of Protein by Chemical Probe in Living Cells for Structural and Interaction Studies. Chembiochem. 2025;26(1):e202400715. [Content Brief]
