3059496-56-6
3059496-56-6
Chemical Structure
KRAS inhibitor-40
- CAS No.: 3059496-56-6
- Formula:C53H68ClF4N9O8S
- Molecular Weight:1102.67
SMILES: O=C([C@H](F)Cl)N1CCC(C(N([C@H](C(N[C@H](C(N2N[C@H](C(OCC(C)(C)CC3=C(C4=C([C@H](C)OC)N=CC(N5CCOCC5)=C4)N6CC(F)(F)C7)=O)CCC2)=O)CC8=NC(C9=CC7C6C3=C9)=CS8)=O)C(C)C)C)=O)(F)CC1
Biological Activity: KRAS inhibitor-40 (Compound 41) is a KRAS inhibitor that interferes with the KRAS G12C-BRAF complex. KRAS inhibitor-40 inhibits the ERK phosphorylation of KRAS downstream signaling pathway. KRAS inhibitor-40 can inhibit the proliferation of tumor cells with different KRAS mutation types and has antitumor activity[1].
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KRAS inhibitor-40 | KRAS inhibitor-40 (Compound 41) is a KRAS inhibitor that interferes with the KRAS G12C-BRAF complex. KRAS inhibitor-40 inhibits the ERK phosphorylation of KRAS downstream signaling pathway. KRAS inhibitor-40 can inhibit the proliferation of tumor cells with different KRAS mutation types and has antitumor activity. | |||||||||||||||||||||
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