3059671-44-9
3059671-44-9
Chemical Structure
AKR1C3-IN-15
- CAS No.: 3059671-44-9
- Formula:C19H16FNO4
- Molecular Weight:341.33
InChIKey: OQIUBBLCWUHZFT-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(C=C(C=C2)F)OC1)N(CC3=CC=C(C=C3)C(O)=O)C
Biological Activity: AKR1C3-IN-15 (compound 30) is a potent and selective AKR1C3 inhibitor with an IC50 of 5 nM. AKR1C3-IN-15 enhances Sorafenib (HY-10201)-induced ROS generation, promoted apoptosis, and restored sorafenib sensitivity in HCC models both in vitro and in vivo[1].
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AKR1C3-IN-15 | AKR1C3-IN-15 (compound 30) is a potent and selective AKR1C3 inhibitor with an IC50 of 5 nM. AKR1C3-IN-15 enhances Sorafenib (HY-10201)-induced ROS generation, promoted apoptosis, and restored sorafenib sensitivity in HCC models both in vitro and in vivo. | |||||||||||||||||||||
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