3060588-16-8
3060588-16-8
Chemical Structure
Aromatase-IN-4
- CAS No.: 3060588-16-8
- Formula:C23H18N6
- Molecular Weight:378.43
InChIKey: FKLUYVFRWAWDLI-UHFFFAOYSA-N
SMILES: C1(NC2=NC=C(NC3=CC=C(C4=NC5=C(N4)C=CC=C5)C=C3)C=C2)=CC=CN=C1
Biological Activity: Aromatase-IN-4 (Compound 6a) is an aromatase (Aromatase) inhibitor. Aromatase-IN-4 exhibits anticancer activity, with GI50 values of 2.95 μM, 3.35 μM, 2.27 μM, 8.46 nM, and 1.56 μM against the MDAMB-231, MCF-7, A-549, NCI-H23, and A-498 cell lines, respectively[1]. Aromatase-IN-4 effectively blocks aromatase-dependent estrogen production[1].
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Aromatase-IN-4 | Aromatase-IN-4 (Compound 6a) is an aromatase (Aromatase) inhibitor. Aromatase-IN-4 exhibits anticancer activity, with GI50 values of 2.95 μM, 3.35 μM, 2.27 μM, 8.46 nM, and 1.56 μM against the MDAMB-231, MCF-7, A-549, NCI-H23, and A-498 cell lines, respectively. Aromatase-IN-4 effectively blocks aromatase-dependent estrogen production. | |||||||||||||||||||||
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