3061406-69-4
Chemical Structure
LGF308
- CAS No.: 3061406-69-4
- Formula:C35H34ClN7O5S2
- Molecular Weight:732.27
InChIKey: VAMVVNOREAQFKY-ZNBSHBAVSA-N
SMILES: O=C(N1CCCCCCNC(C[C@@H]2N=C(C3=C(N4C2=NN=C4C)SC(C)=C3C)C5=CC=C(C=C5)Cl)=O)/C(SC1=O)=C/C6=CC([N+]([O-])=O)=CC=C6
Biological Activity: LGF308 is a PROTAC degrader of BRD4 that exhibits selective cytotoxicity toward cancer cells over normal cells. LGF308 mediates the formation of a ternary complex between BRD4 and DCAF11 to achieve BRD4 degradation. LGF308 induces tumor cell apoptosis by upregulating apoptosis-related proteins. LGF308 inhibits tumor cell proliferation and migration in breast cancer and triple-negative breast cancer cell lines. LGF308 can be used for the research of breast cancer[1].
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LGF308 | LGF308 is a PROTAC degrader of BRD4 that exhibits selective cytotoxicity toward cancer cells over normal cells. LGF308 mediates the formation of a ternary complex between BRD4 and DCAF11 to achieve BRD4 degradation. LGF308 induces tumor cell apoptosis by upregulating apoptosis-related proteins. LGF308 inhibits tumor cell proliferation and migration in breast cancer and triple-negative breast cancer cell lines. LGF308 can be used for the research of breast cancer. | |||||||||||||||||||||
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