3062992-25-7
Chemical Structure
NZ-66
- CAS No.: 3062992-25-7
- Formula:C48H40F8N8O5
- Molecular Weight:960.87
InChIKey: GPTQFSRULLJJIZ-HUESYALOSA-N
SMILES: O=C(NC1=CC=C(F)C=C1F)[C@H](NC(NC2=CC(C(F)(F)F)=CC(C(F)(F)F)=C2)=O)C3=CC=C(OCC4=CN(CCCCCCNC(C(C5=C(C6=CC=CC=C6)NC7=C5C=CC=C7)=O)=O)N=N4)C=C3
Biological Activity: NZ-66 is a ULK1-Recruiting Chimera (ULKREC) and heterobifunctional chimeric molecule composed of a BL-918-derived ULK1 agonist linked to a mitochondrial outer membrane-targeting TSPO ligand via a six-carbon hexane linker. NZ-66 is a mitophagy inducer recruits ULK1 to mitochondria to induce ULK1-dependent mitophagy, enhanced by mitochondrial insult, independently of the PRKN/PINK axis. NZ-66 can be used for the research of parkinson’s disease[1].
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NZ-66 | NZ-66 is a ULK1-Recruiting Chimera (ULKREC) and heterobifunctional chimeric molecule composed of a BL-918-derived ULK1 agonist linked to a mitochondrial outer membrane-targeting TSPO ligand via a six-carbon hexane linker. NZ-66 is a mitophagy inducer recruits ULK1 to mitochondria to induce ULK1-dependent mitophagy, enhanced by mitochondrial insult, independently of the PRKN/PINK axis. NZ-66 can be used for the research of parkinson’s disease. | |||||||||||||||||||||
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