3063509-17-8
Chemical Structure
THR-β agonist 12
- CAS No.: 3063509-17-8
- Formula:C17H9Cl3F3NO3
- Molecular Weight:438.61
InChIKey: NXAJVBYFVFHYCW-UHFFFAOYSA-N
SMILES: ClC1=C2C(NC(C(O)=O)=C2)=CC(Cl)=C1OCC3=C(C(C(F)(F)F)=CC=C3)Cl
Biological Activity: THR-β agonist 12 is an orally active, potent, and highly selective thyroid hormone receptor β (THR-β) agonist (EC50 = 36 nM). THR-β agonist 12 shows no significant activity against THRα and exhibits no cardiotoxicity in vivo. THR-β agonist 12 inhibits lipid synthesis by activating the AMPK-ACC-SREBP1 signaling axis. THR-β agonist 12 can be used on research into metabolic dysfunction-associated steatohepatitis (MASH) and related metabolic diseases[1].
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THR-β agonist 12 | THR-β agonist 12 is an orally active, potent, and highly selective thyroid hormone receptor β (THR-β) agonist (EC50 = 36 nM). THR-β agonist 12 shows no significant activity against THRα and exhibits no cardiotoxicity in vivo. THR-β agonist 12 inhibits lipid synthesis by activating the AMPK-ACC-SREBP1 signaling axis. THR-β agonist 12 can be used on research into metabolic dysfunction-associated steatohepatitis (MASH) and related metabolic diseases. | |||||||||||||||||||||
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