3064481-29-1
3064481-29-1
Chemical Structure
USP1-IN-18
- CAS No.: 3064481-29-1
- Formula:C26H22F3N7O2
- Molecular Weight:521.49
InChIKey: VUGUCQFCHBQSFE-UHFFFAOYSA-N
SMILES: COC1=NC=NC(C2CC2)=C1C3=CC(N(CC4=CC=C(C5=NC(C(F)(F)F)=CN5C)C=C4)C(N6)=O)=C6C=N3
Biological Activity: USP1-IN-18 is an orally active USP1 inhibitor with a human IC50 of 17.0 nM. USP1-IN-18 inhibits USP1-UAF1 deubiquitinase activity and drives ubiquitinated PCNA accumulation. USP1-IN-18 induces DNA damage, replication stress, and G2-M phase cell cycle arrest. USP1-IN-18 can be used for the research of triple-negative breast cancer[1].
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USP1-IN-18 | USP1-IN-18 is an orally active USP1 inhibitor with a human IC50 of 17.0 nM. USP1-IN-18 inhibits USP1-UAF1 deubiquitinase activity and drives ubiquitinated PCNA accumulation. USP1-IN-18 induces DNA damage, replication stress, and G2-M phase cell cycle arrest. USP1-IN-18 can be used for the research of triple-negative breast cancer. | |||||||||||||||||||||
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