3064599-36-3
Chemical Structure
GSK4418959
Synonym(s): IDE275
- CAS No.: 3064599-36-3
- Formula:C31H30F4N4O5S
- Molecular Weight:646.65
InChIKey: CPNRNECAIBPHJF-MVOZIGHISA-N
SMILES: O=C(NC1=CC=C(C(F)(F)F)C=C1F)[C@@H]2CCC[C@H](C3=CC=C(N(C)S(=O)(C4=CC(N=C(C)N5C)=C5C=C4)=O)C=C3)[C@H]2C(O)=O
Biological Activity: GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC)[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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GSK4418959 | 99.07% | GSK4418959 (IDE275) is a selective, reversible and orally active WRN helicase inhibitor. GSK4418959 shows >10,000-fold selectivity over other helicases. GSK4418959 inhibits ATPase and DNA unwinding functions in an ATP-competitive manner. GSK4418959 can be used for the study of microsatellite instability-high (MSI-H) cancer, such as colorectal cancer (CRC) and endometrial cancer (EC). | ||||||||||||||||||||
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