3064994-97-1
Chemical Structure
PROTAC CDK4/6/9 degrader 1
- CAS No.: 3064994-97-1
- Formula:C51H62N12O7
- Molecular Weight:955.11
InChIKey: BUTVQTUNKDPXBW-UHFFFAOYSA-N
SMILES: O=C(C1=CC2=C(N=C(N=C2)NC3=CC=C(C=C3)C(CN4CCN(CC4)CC5CCN(CC5)CC(N6CCN(CC6)C7=CC=C(C8=C7)C(N(C8=O)C9CCC(NC9=O)=O)=O)=O)=O)N1C%10CCCC%10)N(C)C
Biological Activity: PROTAC CDK4/6/9 degrader 1 is a CDK4/6/9 PROTAC degrader. PROTAC CDK4/6/9 degrader 1 degrades CDK4, CDK6, and CDK9 in TNBC cells and inhibits TNBC cell proliferation. PROTAC CDK4/6/9 degrader 1 induces G1 phase arrest, promotes apoptosis, and suppresses cell migration and invasion in TNBC cells. PROTAC CDK4/6/9 degrader 1 can be used for the study of triple-negative breast cancer (TNBC). (Pink: CDK4/6/9 ligand (HY-168440), Blue: CRBN Ligand (HY-14658), Black: Linker (HY-178512), E3 ligase ligand-linker conjugate (HY-178515))[1].
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PROTAC CDK4/6/9 degrader 1 | PROTAC CDK4/6/9 degrader 1 is a CDK4/6/9 PROTAC degrader. PROTAC CDK4/6/9 degrader 1 degrades CDK4, CDK6, and CDK9 in TNBC cells and inhibits TNBC cell proliferation. PROTAC CDK4/6/9 degrader 1 induces G1 phase arrest, promotes apoptosis, and suppresses cell migration and invasion in TNBC cells. PROTAC CDK4/6/9 degrader 1 can be used for the study of triple-negative breast cancer (TNBC). (Pink: CDK4/6/9 ligand (HY-168440), Blue: CRBN Ligand (HY-14658), Black: Linker (HY-178512), E3 ligase ligand-linker conjugate (HY-178515)). | |||||||||||||||||||||
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