3065634-42-3
Chemical Structure
RIPK1-IN-39
- CAS No.: 3065634-42-3
- Formula:C29H24FN5O2S
- Molecular Weight:525.60
InChIKey: NMRJIJSFDSHCBZ-HNNXBMFYSA-N
SMILES: O=C(C1CC1)NC2=NC3=C(S2)C=C(C4=CC=C5C(C(C(N[C@@H](C)C6=CC=C(F)C=C6)=O)=NC(C)=N5)=C4)C=C3
Biological Activity: RIPK1-IN-39 (compound 2) is a potent and selective RIPK1 inhibitor (IC50 = 69.40 nM) exhibiting >100-fold selectivity over RIPK3 (IC50 = 6946 nM). RIPK1-IN-39 protects HT-22 and HT-29 cells from necroptosis by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL pathway. RIPK1-IN-39 demonstrates neuroprotective effects in a rat model of middle cerebral artery occlusion (MCAO). RIPK1-IN-39 can be used for acute ischemic stroke (AIS) research[1].
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RIPK1-IN-39 | RIPK1-IN-39 (compound 2) is a potent and selective RIPK1 inhibitor (IC50 = 69.40 nM) exhibiting >100-fold selectivity over RIPK3 (IC50 = 6946 nM). RIPK1-IN-39 protects HT-22 and HT-29 cells from necroptosis by inhibiting the phosphorylation and activation of the RIPK1-RIPK3-MLKL pathway. RIPK1-IN-39 demonstrates neuroprotective effects in a rat model of middle cerebral artery occlusion (MCAO). RIPK1-IN-39 can be used for acute ischemic stroke (AIS) research. | |||||||||||||||||||||
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