3066972-97-9
3066972-97-9
Chemical Structure
VEGFR-2-IN-58
- CAS No.: 3066972-97-9
- Formula:C24H16ClN3O
- Molecular Weight:397.86
InChIKey: IHYBNWZDUVAZNY-UHFFFAOYSA-N
SMILES: N#CC1=C(/N=C/NC2=CC=C(Cl)C=C2)OC(C3=CC=CC=C3)=C1C4=CC=CC=C4
Biological Activity: VEGFR-2-IN-58 (Compound 7b) inhibits VEGFR-2 with an IC50 of 42.5 nM. VEGFR-2-IN-58 displays selective cytotoxicity against cancer cells. VEGFR-2-IN-58 shows cellular growth arrest at the G2/M phase in cancer cells. VEGFR-2-IN-58 induces cancer cells Apoptosis, increasing BAX expression and reducing Bcl2 expression. VEGFR-2-IN-58 inhibits wound closure in cancer cells[1].
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VEGFR-2-IN-58 | VEGFR-2-IN-58 (Compound 7b) inhibits VEGFR-2 with an IC50 of 42.5 nM. VEGFR-2-IN-58 displays selective cytotoxicity against cancer cells. VEGFR-2-IN-58 shows cellular growth arrest at the G2/M phase in cancer cells. VEGFR-2-IN-58 induces cancer cells Apoptosis, increasing BAX expression and reducing Bcl2 expression. VEGFR-2-IN-58 inhibits wound closure in cancer cells. | |||||||||||||||||||||
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