3069975-17-0
Chemical Structure
JWJ-01-306
- CAS No.: 3069975-17-0
- Formula:C28H26ClF3N4O4
- Molecular Weight:574.98
InChIKey: ZPHOUUGPVJCEAJ-UHFFFAOYSA-N
SMILES: FC(F)(F)C1=C(Cl)C=CC(CCNC2(CCC2)C3=CC(NC(C(N4C5CCC(NC5=O)=O)=O)=CC4=O)=CC=C3)=C1
Biological Activity:
JWJ-01-306 is a CRBN-recruiting ZBTB11 Molecular Glues degrader. JWJ-01-306 degrades ZBTB11 and reprograms cellular metabolism, thereby reducing the level of Oxidative Phosphorylation and the activity of the tricarboxylic acid cycle. JWJ-01-306 enhances the response of organoids to K-Ras inhibition. JWJ-01-306 inhibits the proliferation of pancreatic ductal adenocarcinoma cells and melanoma cells. JWJ-01-306 can be used in studies related to pancreatic ductal adenocarcinoma and melanoma[1][2].
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JWJ-01-306 | JWJ-01-306 is a CRBN-recruiting ZBTB11 Molecular Glues degrader. JWJ-01-306 degrades ZBTB11 and reprograms cellular metabolism, thereby reducing the level of Oxidative Phosphorylation and the activity of the tricarboxylic acid cycle. JWJ-01-306 enhances the response of organoids to K-Ras inhibition. JWJ-01-306 inhibits the proliferation of pancreatic ductal adenocarcinoma cells and melanoma cells. JWJ-01-306 can be used in studies related to pancreatic ductal adenocarcinoma and melanoma. |
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References
- [1]. Tran NL, et al.. ZBTB11 depletion targets metabolic vulnerabilities in KRAS inhibitor-resistant PDAC. Nat Chem Biol. 2026 Feb;22(2):260-273. [Content Brief]
- [2]. Jiang J, et al. Synthesis and Structure-Activity Relationships of CRBN-Recruiting ZBTB11 Molecular Glue Degraders. J Med Chem. 2025;68(18):19287-19302. [Content Brief]
