3070509-60-0
Chemical Structure
NF-κB/MAPK-IN-2
- CAS No.: 3070509-60-0
- Formula:C49H66N2O9
- Molecular Weight:827.06
InChIKey: CNDQUTRROVUJEL-WGUFGIACSA-N
SMILES: C[C@]1(C2=C(C[C@]3([C@@]1([H])CC[C@@]4([C@]3([H])CC=C5[C@]4(CC[C@@]6([C@@]5([H])CC(C)(CC6)C)C(OCC7=CC=CC=C7)=O)C)C)C)C(C(OCC)=O)=NO2)COC(CCC(N8CCOCC8)=O)=O
Biological Activity: NF-κB/MAPK-IN-2 (compound 14) is a potent NF-κB and MAPK Inhibitor. NF-κB/MAPK-IN-2 decreases the protein expression of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. NF-κB/MAPK-IN-2 reduces the LPS-induced release of TNF-α and IL-6. NF-κB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 has the potential for the research of sepsis[1].
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NF-κB/MAPK-IN-2 | NF-κB/MAPK-IN-2 (compound 14) is a potent NF-κB and MAPK Inhibitor. NF-κB/MAPK-IN-2 decreases the protein expression of p-p65, p-IκB, p-p38, p-JNK, and p-ERK. NF-κB/MAPK-IN-2 reduces the LPS-induced release of TNF-α and IL-6. NF-κB/MAPK-IN-2 inhibits nuclear translocation of p65 and c-Fos. NF-κB/MAPK-IN-2 has the potential for the research of sepsis. | |||||||||||||||||||||
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