3071928-57-6
3071928-57-6
Chemical Structure
LY3972406
- CAS No.: 3071928-57-6
- Formula:C16H23ClN2O4·1/2C5H8O4·1/2H2O
- Molecular Weight:492.95
SMILES: ClC1=C(C)C=C(O)C([C@H](N)C2CCN(C([C@H](O)CO)=O)CC2)=C1.O=C(CCCC(O)=O)O.O.[1/2].[1/2]
Biological Activity: LY3972406 is an orally active, selective Kv1.3 antagonist. LY3972406 acts on chronically stimulated effector memory T cells without affecting naive central memory T cells. LY3972406 induces mild, non-adverse skin irritation in Rattus norvegicus. LY3972406 is applicable for the research of autoimmune diseases[1][2].
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LY3972406 | LY3972406 is an orally active, selective Kv1.3 antagonist. LY3972406 acts on chronically stimulated effector memory T cells without affecting naive central memory T cells. LY3972406 induces mild, non-adverse skin irritation in Rattus norvegicus. LY3972406 is applicable for the research of autoimmune diseases. | |||||||||||||||||||||
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References
- [1]. Li X, et al. Development of a Scalable Manufacturing Process for Kv1. 3 Antagonist LY3972406 Hemiglutarate Hemihydrate[J]. Organic Process Research & Development, 2026.
- [2]. Franklin KM, et al. Safety Evaluation of Glutaric Acid as a Novel Pharmaceutical Salt for First-In-Human Dosing. Toxicol Sci. 2026 May 21:kfag059. [Content Brief]
