3073704-71-6
3073704-71-6
Chemical Structure
FUT8-IN-1
- CAS No.: 3073704-71-6
- Formula:C23H25ClN2O
- Molecular Weight:380.91
InChIKey: MVJJVQCBAQZSIF-UHFFFAOYSA-N
SMILES: ClC1=CC=C2C(C=CC(O)=C2CN3CCN(CC)CC3C4=CC=CC=C4)=C1
Biological Activity: FUT8-IN-1 (Compound 37) is an inhibitor for α-1,6-fucosyltransferase (FUT8) with an KD of 49 nM and an IC50 of ca. 50 µM. FUT8-IN-1 generates a highly active naphthoquinone imine intermediate in the presence of FUT8, and inhibits the enzymatic activity of FUT8[1].
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FUT8-IN-1 | FUT8-IN-1 (Compound 37) is an inhibitor for α-1,6-fucosyltransferase (FUT8) with an KD of 49 nM and an IC50 of ca. 50 µM. FUT8-IN-1 generates a highly active naphthoquinone imine intermediate in the presence of FUT8, and inhibits the enzymatic activity of FUT8. | |||||||||||||||||||||
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