3075541-07-7
3075541-07-7
Chemical Structure
FLT3-IN-40
- CAS No.: 3075541-07-7
- Formula:C24H22N6O2
- Molecular Weight:426.47
InChIKey: CFCAHQYNMKPMRM-UHFFFAOYSA-N
SMILES: COC1=CC(OC)=C(C=C1)NC2=CC=CC(C3=CN=C4C=C(C=CN34)C5=CN(N=C5)C)=N2
Biological Activity: FLT3-IN-40 is a type I ATP-competitive FLT3 inhibitor with an IC50 of 16.26 nM. FLT3-IN-40 reduces the autophosphorylation level of FLT3 and the phosphorylation level of downstream ERK. FLT3-IN-40 exhibits antiproliferative, cell cycle regulatory and apoptosis-inducing activities. FLT3-IN-40 can be used in research related to acute myeloid leukemia[1].
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FLT3-IN-40 | FLT3-IN-40 is a type I ATP-competitive FLT3 inhibitor with an IC50 of 16.26 nM. FLT3-IN-40 reduces the autophosphorylation level of FLT3 and the phosphorylation level of downstream ERK. FLT3-IN-40 exhibits antiproliferative, cell cycle regulatory and apoptosis-inducing activities. FLT3-IN-40 can be used in research related to acute myeloid leukemia. | |||||||||||||||||||||
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