3075572-35-6
3075572-35-6
Chemical Structure
TBK1-IN-2
- CAS No.: 3075572-35-6
- Formula:C26H29N7O5
- Molecular Weight:519.55
InChIKey: SSQZPFMYCNLFRT-UHFFFAOYSA-N
SMILES: COC1=C(OC)C=C2C(N=C(C3=NNC=C3NC(N4CCC(NC(OCC5=CC=CC=C5)=O)CC4)=O)N2)=C1
Biological Activity: TBK1-IN-2 (Compound A1) is a potent TBK1 inhibitor (IC50: 775 pM). TBK1-IN-2 binds to TBK1 through stable hydrogen bonds and π-π stacking, inhibiting IRF3 phosphorylation. TBK1-IN-2 synergizes with TNF/IFNγ to enhance immune-mediated tumor cell death. TBK1-IN-2 can be used in cancer immunotherapy research[1].
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TBK1-IN-2 | 98.19% | TBK1-IN-2 (Compound A1) is a potent TBK1 inhibitor (IC50: 775 pM). TBK1-IN-2 binds to TBK1 through stable hydrogen bonds and π-π stacking, inhibiting IRF3 phosphorylation. TBK1-IN-2 synergizes with TNF/IFNγ to enhance immune-mediated tumor cell death. TBK1-IN-2 can be used in cancer immunotherapy research. | ||||||||||||||||||||
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