3076328-71-4
3076328-71-4
Chemical Structure
FAP targeting peptide-PEG2 conjugate
- CAS No.: 3076328-71-4
- Formula:C73H102N16O18
- Molecular Weight:1491.69
InChIKey: GSZHNIOZMWDONQ-MKGFAGGUSA-N
SMILES: O=C([C@@H](NC([C@@H](NC([C@@H](N(C(CNC(CNC([C@]1([H])N(CCC1)C([C@@H](NC([C@@H](NC(CNC2=O)=O)CCCCNC(N3CCN(CC3)CC(O)=O)=O)=O)CC(O)=O)=O)=O)=O)=O)C)CC4=CC=CC=C4)=O)CC5=CC=C(C=C5)CNC(COCCOCCN)=O)=O)CCCCCC)N[C@H]2CC6=CNC7=CC=CC=C67
Biological Activity: FAP targeting peptide-PEG2 conjugate (Example A1) is the peptide (HY-P10945) and linker conjugate of Unlabeled FXX489 (HY-P10944). Unlabeled FXX489 is a fibroblast activation protein (FAP)-targeting ligand[1][2].
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FAP targeting peptide-PEG2 conjugate | FAP targeting peptide-PEG2 conjugate (Example A1) is the peptide (HY-P10945) and linker conjugate of Unlabeled FXX489 (HY-P10944). Unlabeled FXX489 is a fibroblast activation protein (FAP)-targeting ligand. | |||||||||||||||||||||
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References
- [1]. Ravit Geva, et al. Abstract CT112: Phase I open-label, multi-center study to evaluate the safety, tolerability, dosimetry, and preliminary activity of FXX489 ([177Lu]Lu-NNS309) in patients with pancreatic, lung, breast and colorectal cancers. Cancer Res (2025) 85 (8_Supplement_2): CT112.
- [2]. Salvatore BONGARZONE, et al. Fap targeting cyclic peptides and conjugates thereof. WO2025037249A1.
