3077252-76-4
3077252-76-4
Chemical Structure
MTHFD2-IN-6
- CAS No.: 3077252-76-4
- Formula:C21H21ClO5
- Molecular Weight:388.84
InChIKey: NQXAJRWSQLMCOM-RMKNXTFCSA-N
SMILES: O=C(C1=C(O)C=C(O)C(C/C=C(C)\C)=C1O)/C=C/C2=CC=C(Cl)C(OC)=C2
Biological Activity: MTHFD2-IN-6 is an orally active selective inhibitor of MTHFD2, with a human IC50 of 1.46 μM. MTHFD2-IN-6 binds directly to MTHFD2, selectively inhibits cancer cell proliferation, promotes ROS accumulation in cancer cells, and induces cancer cell cycle arrest and apoptosis. MTHFD2-IN-6 inhibits tumor growth in Mus musculus xenograft models. MTHFD2-IN-6 can be used for lung cancer research[1].
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MTHFD2-IN-6 | MTHFD2-IN-6 is an orally active selective inhibitor of MTHFD2, with a human IC50 of 1.46 μM. MTHFD2-IN-6 binds directly to MTHFD2, selectively inhibits cancer cell proliferation, promotes ROS accumulation in cancer cells, and induces cancer cell cycle arrest and apoptosis. MTHFD2-IN-6 inhibits tumor growth in Mus musculus xenograft models. MTHFD2-IN-6 can be used for lung cancer research. | |||||||||||||||||||||
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