3077316-17-4
Chemical Structure
EGFR-IN-214
- CAS No.: 3077316-17-4
- Formula:C39H37F3N2O11
- Molecular Weight:766.71
InChIKey: ICZSOVFFVYHXNZ-QXVNFQQESA-N
SMILES: O=C1C(O[C@H]2[C@H](O)[C@H](O)[C@@H](O)[C@H](C)O2)=C(C3=CC=C(OC)C=C3)OC4=C1C(O)=CC(OCC5=NN=C(/C=C/C6=CC=C(C(F)(F)F)C=C6)O5)=C4C/C=C(C)\C
Biological Activity: EGFR-IN-214 is an orally active EGFR inhibitor with an EC50 of 3.353 μM. EGFR-IN-214 blocks the downstream PI3K/Akt signaling pathway, induces intracellular ROS accumulation and Caspase-dependent apoptosis. EGFR-IN-214 exhibits antiproliferative activity in cancer cells and inhibits tumor growth in xenograft models. EGFR-IN-214 can be used in studies related to hepatocellular carcinoma[1].
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EGFR-IN-214 | EGFR-IN-214 is an orally active EGFR inhibitor with an EC50 of 3.353 μM. EGFR-IN-214 blocks the downstream PI3K/Akt signaling pathway, induces intracellular ROS accumulation and Caspase-dependent apoptosis. EGFR-IN-214 exhibits antiproliferative activity in cancer cells and inhibits tumor growth in xenograft models. EGFR-IN-214 can be used in studies related to hepatocellular carcinoma. | |||||||||||||||||||||
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