3077918-47-6
3077918-47-6
Chemical Structure
PROTAC DHFR Degrader-1
- CAS No.: 3077918-47-6
- Formula:C53H60Cl2F2N8O9
- Molecular Weight:1061.99
InChIKey: IXFZWVFOAUJQKN-DLIBPESQSA-N
SMILES: O=C(NCCOCCOC1=CC=C(OCCCOC2=C(N=C(N=C2CC)N)N)C(CCC(O)=O)=C1)C3=CC(OC)=C(NC([C@@H]4N[C@@H](CC(C)(C)C)[C@]([C@H]4C5=CC=CC(Cl)=C5F)(C#N)C6=CC=C(Cl)C=C6F)=O)C=C3
Biological Activity: PROTAC DHFR Degrader-1 is a selective PROTAC degrader targeting Plasmodium falciparum DHFR-TS with a Ki of 2.01 nM. PROTAC DHFR Degrader-1 exhibits no inhibitory activity against human DHFR and suppresses the growth of Plasmodium falciparum. PROTAC DHFR Degrader-1 can be used for the research of Plasmodium falciparum and malaria[1].
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PROTAC DHFR Degrader-1 | PROTAC DHFR Degrader-1 is a selective PROTAC degrader targeting Plasmodium falciparum DHFR-TS with a Ki of 2.01 nM. PROTAC DHFR Degrader-1 exhibits no inhibitory activity against human DHFR and suppresses the growth of Plasmodium falciparum. PROTAC DHFR Degrader-1 can be used for the research of Plasmodium falciparum and malaria. | |||||||||||||||||||||
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