3077970-44-3
3077970-44-3
Chemical Structure
Nampt-IN-16
- CAS No.: 3077970-44-3
- Formula:C25H25FN4O3
- Molecular Weight:448.49
InChIKey: ULMUOHYPKGDIMQ-UHFFFAOYSA-N
SMILES: O=C(NC1=CC=C(CNC(C2=C(N3CCCC3)C=CC(F)=C2)=O)C=C1)OCC4=CC=CN=C4
Biological Activity: Nampt-IN-16 (Compound 9a) is an orally active NAMPT inhibitor with an IC50 of 0.15 μM. Nampt-IN-16 can reduce intracellular NAD+ and ATP levels. Nampt-IN-16 can inhibit the proliferation, migration, and invasion, induce cell cycle arrest and apoptosis, and alter cellular metabolism of gastric cancer cells. Nampt-IN-16 can be used in the research of tumors such as gastric cancer[1].
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Nampt-IN-16 | Nampt-IN-16 (Compound 9a) is an orally active NAMPT inhibitor with an IC50 of 0.15 μM. Nampt-IN-16 can reduce intracellular NAD+ and ATP levels. Nampt-IN-16 can inhibit the proliferation, migration, and invasion, induce cell cycle arrest and apoptosis, and alter cellular metabolism of gastric cancer cells. Nampt-IN-16 can be used in the research of tumors such as gastric cancer. | |||||||||||||||||||||
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