3077970-78-3
Chemical Structure
Nampt-IN-17
- CAS No.: 3077970-78-3
- Formula:C26H28FN5O2
- Molecular Weight:461.53
InChIKey: AJACMNSTFIIEJW-SFHVURJKSA-N
SMILES: FC1=CC=C(C(C(N[C@H](C2=CC=C(C=C2)NC(NCC3=CC=CN=C3)=O)C)=O)=C1)N4CCCC4
Biological Activity: Nampt-IN-17 is an selective orally active NAMPT inhibitor with a human NAMPT IC50 of 17 nM and Ki of 25.9 nM. Nampt-IN-17 depletes intracellular NAD+ and ATP, disrupts mitochondrial membrane potential, suppresses cell proliferation, self-renewal, invasion, and migration, induces cell-cycle arrest and apoptosis. Nampt-IN-17 exhibits selective activity against NAPRT-deficient gastric cancer cells. Nampt-IN-17 can be used for the research of NAPRT-deficient gastric cancer[1].
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Nampt-IN-17 | Nampt-IN-17 is an selective orally active NAMPT inhibitor with a human NAMPT IC50 of 17 nM and Ki of 25.9 nM. Nampt-IN-17 depletes intracellular NAD+ and ATP, disrupts mitochondrial membrane potential, suppresses cell proliferation, self-renewal, invasion, and migration, induces cell-cycle arrest and apoptosis. Nampt-IN-17 exhibits selective activity against NAPRT-deficient gastric cancer cells. Nampt-IN-17 can be used for the research of NAPRT-deficient gastric cancer. | |||||||||||||||||||||
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