3078276-74-8
Chemical Structure
MOMA-341
- CAS No.: 3078276-74-8
- Formula:C28H26F4N6O3
- Molecular Weight:570.54
IUPAC Name: (R)-1-(5-(4-amino-5-fluoro-6-(trifluoromethyl)nicotinoyl)-2-(4-cyclopropyl-2-hydroxyphenyl)-2,3,4,5,5a,6,8,9-octahydro-7H-1,2,5,7-tetraazabenzo[cd]azulen-7-yl)prop-2-en-1-one
InChIKey: XGLVNFVYNNRPRE-FQEVSTJZSA-N
SMILES: C=CC(N1CCC2=NN(C3=C2[C@@H](N(CC3)C(C4=C(C(F)=C(N=C4)C(F)(F)F)N)=O)C1)C5=CC=C(C=C5O)C6CC6)=O
Biological Activity: MOMA-341 is a selective Werner RecQ like helicase (WRN) inhibitor. MOMA-341 binds to WRN at cysteine 727 through an allosteric and ATP-competitive binding mechanism. MOMA-341 has antitumor activity and can be used for advanced and metastatic solid tumors research[1].
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MOMA-341 | MOMA-341 is a selective Werner RecQ like helicase (WRN) inhibitor. MOMA-341 binds to WRN at cysteine 727 through an allosteric and ATP-competitive binding mechanism. MOMA-341 has antitumor activity and can be used for advanced and metastatic solid tumors research. | |||||||||||||||||||||
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