3078322-88-7
Chemical Structure
PRMT5-MTA-IN-5
- CAS No.: 3078322-88-7
- Formula:C27H24FN7O
- Molecular Weight:481.52
InChIKey: KFTISLTZGQGUHY-UHFFFAOYSA-N
SMILES: NCC1=NNC(C2=C(C=C)C=C(C3=[C@]([C@]4=C(C#N)C(N5CC(C5)=C)=CC(C)=C4F)N(C)N=C3)C=C21)=O
Biological Activity: PRMT5-MTA-IN-5 (Compound 7) is an orally active, irreversible PRMT5-MTA complex (PRMT5•MTA) inhibitor (IC50=1.15 nM). PRMT5-MTA-IN-5 blocks arginine methylation and inhibits ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-5 potently inhibits proliferation in MTAP-deficient tumor cells. PRMT5-MTA-IN-5 is promising for research of MTAP-deficient solid tumors, such as liver, breast, and pancreatic cancers[1].
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PRMT5-MTA-IN-5 | PRMT5-MTA-IN-5 (Compound 7) is an orally active, irreversible PRMT5-MTA complex (PRMT5•MTA) inhibitor (IC50=1.15 nM). PRMT5-MTA-IN-5 blocks arginine methylation and inhibits ribosomal RNA processing and cell cycle-related protein expression. PRMT5-MTA-IN-5 potently inhibits proliferation in MTAP-deficient tumor cells. PRMT5-MTA-IN-5 is promising for research of MTAP-deficient solid tumors, such as liver, breast, and pancreatic cancers. | |||||||||||||||||||||
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