3078541-89-3
3078541-89-3
Chemical Structure
PF-184
- CAS No.: 3078541-89-3
- Formula:C32H32ClFN6O4
- Molecular Weight:619.09
IUPAC Name: N,N,N-trimethylhexadecan-1-aminium-d33 bromide
InChIKey: JUOWWGNRWRLBSV-MEKGRNQZSA-N
SMILES: O=C(C1=NN(C2=C1CCC3=C2C=C(NC(C4=CC(N5C[C@](CO)([C@](CO)(C5)C)C)=NC=C4Cl)=O)C=C3)C6=CC=C(C=C6)F)N
Biological Activity: PF-184 is a potent and selective IKK-2 inhibitor (IC50: 37 nM) over rhIKK-1, IKKi, and more than 30 tyrosine and serine/threonine kinases. PF-184 can be used in the research of inflammation, such as asthma and chronic obstructive pulmonary disease[1].
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PF-184 | PF-184 is a potent and selective IKK-2 inhibitor (IC50: 37 nM) over rhIKK-1, IKKi, and more than 30 tyrosine and serine/threonine kinases. PF-184 can be used in the research of inflammation, such as asthma and chronic obstructive pulmonary disease. | |||||||||||||||||||||
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References
- [1]. Cynthia D Sommers, et al. Novel tight-binding inhibitory factor-kappaB kinase (IKK-2) inhibitors demonstrate target-specific anti-inflammatory activities in cellular assays and following oral and local delivery in an in vivo model of airway inflammation. J Pharmacol Exp Ther. 2009 Aug;330(2):377-88. [Content Brief]
