3080542-96-4
3080542-96-4
Chemical Structure
GBM CSCs-IN-1
- CAS No.: 3080542-96-4
- Formula:C28H29BrN2O8S
- Molecular Weight:633.51
InChIKey: YZIDMFNIQMDOPV-GWNOIRNCSA-N
SMILES: COC1=C2C(O[C@]3(C4=CC=C(Br)C=C4)[C@@]2(O)[C@H](O)[C@H](C(NS(N(C)C)(=O)=O)=O)[C@H]3C5=CC=CC=C5)=CC(OC)=C1
Biological Activity: GBM CSCs-IN-1 (Compound (−)-20), a derivative of rocaglate, is a potent inhibitor of glioblastoma stem cells (GBM CSCs) with an EC50 of 45 nM, functioning by targeting the RNA helicase DDX3. Furthermore, GBM CSCs-IN-1 is also capable of inducing apoptosis[1].
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GBM CSCs-IN-1 | GBM CSCs-IN-1 (Compound (−)-20), a derivative of rocaglate, is a potent inhibitor of glioblastoma stem cells (GBM CSCs) with an EC50 of 45 nM, functioning by targeting the RNA helicase DDX3. Furthermore, GBM CSCs-IN-1 is also capable of inducing apoptosis. | |||||||||||||||||||||
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