3080678-93-6
3080678-93-6
Chemical Structure
PROTAC LRRK2 Degrader-2
- CAS No.: 3080678-93-6
- Formula:C43H53N11O5
- Molecular Weight:803.95
InChIKey: OOSAURFFLPZWEZ-ZPXLLAHRSA-N
SMILES: O=C1N(C2C(NC(CC2)=O)=O)C3=CC=C(N4CCC(CC4)O[C@@H]5CC[C@H](CC5)CN6CCN(C7=NC=NC(C(C8=C9)=NNC8=CN=C9OC%10(CC%10)C)=C7)CC6)C=C3N1C
Biological Activity: PROTAC LRRK2 Degrader-2 is a PROTAC-based degrader targeting LRRK2 with a DC50 of 0.14 nM. PROTAC LRRK2 Degrader-2 recruits LRRK2 or its mutants to the cereblon E3 ubiquitin ligase, thereby mediating the targeted ubiquitination and subsequent proteasomal degradation of LRRK2. PROTAC LRRK2 Degrader-2 can be used in research related to Parkinson's disease[1].
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PROTAC LRRK2 Degrader-2 | PROTAC LRRK2 Degrader-2 is a PROTAC-based degrader targeting LRRK2 with a DC50 of 0.14 nM. PROTAC LRRK2 Degrader-2 recruits LRRK2 or its mutants to the cereblon E3 ubiquitin ligase, thereby mediating the targeted ubiquitination and subsequent proteasomal degradation of LRRK2. PROTAC LRRK2 Degrader-2 can be used in research related to Parkinson's disease. | |||||||||||||||||||||
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