3081054-21-6
![Tyr-c[D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 Chemical Structure](http://file.medchemexpress.cn/product_pic/hy-p11895.gif "Tyr-c[D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 Chemical Structure")
Chemical Structure
Tyr-c[D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2
- CAS No.: 3081054-21-6
- Formula:C42H51FN8O8
- Molecular Weight:814.90
InChIKey: JCZSCUPNYZXYDA-JABDCJIOSA-N
SMILES: OC1=CC=C(C[C@H](N)C(N[C@@H](C(N[C@@H](CC2=CC=C(F)C=C2)C(N[C@@H](CC3=CC=CC=C3)C(N[C@H](C(N4CCC[C@@H]4C(N)=O)=O)C5)=O)=O)=O)CCCCNC5=O)=O)C=C1
Biological Activity: Tyr-c [D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 is a multi-opioid receptor (Opioid Receptor) modulator, acting as a MOR/KOR agonist and a DOR antagonist. Tyr-c [D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 activates the G protein-mediated cAMP inhibitory pathway and β-arrestin2 recruitment pathway downstream of MOR, with an EC50 of 159 nM for β-arrestin2 recruitment, an EC50 of 1.1 nM for MOR-mediated calcium mobilization, and an EC50 of 397 nM for KOR. Tyr-c [D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 exhibits potent analgesic activity in vivo. It can be used in studies related to opioid receptor function and analgesia[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Tyr-c[D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 | Tyr-c [D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 is a multi-opioid receptor (Opioid Receptor) modulator, acting as a MOR/KOR agonist and a DOR antagonist. Tyr-c [D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 activates the G protein-mediated cAMP inhibitory pathway and β-arrestin2 recruitment pathway downstream of MOR, with an EC50 of 159 nM for β-arrestin2 recruitment, an EC50 of 1.1 nM for MOR-mediated calcium mobilization, and an EC50 of 397 nM for KOR. Tyr-c [D-Lys-p-F-Phe-Phe-Asp]-D-Pro-NH2 exhibits potent analgesic activity in vivo. It can be used in studies related to opioid receptor function and analgesia. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
