3081622-36-5
Chemical Structure
ALK/EGFR-IN-4
- CAS No.: 3081622-36-5
- Formula:C24H29ClN7O4P
- Molecular Weight:545.96
InChIKey: JPGNRNMUXAFODV-UHFFFAOYSA-N
SMILES: CP(C)(C1=CC=CC=C1NC2=NC(NC3=CC([N+]([O-])=O)=C(N4CCN(C)CC4)C=C3OC)=NC=C2Cl)=O
Biological Activity: ALK/EGFR-IN-4 is an EGFR and ALK inhibitor (EGFRL858R/T790M/C797S (IC50 1.76 nM), EGFRL858R/T790M (2.97 nM), wild-type EGFR (59.35 nM) and ALK (1.95 nM)). ALK/EGFR-IN-4 induces G0/G1 phase arrest and Apoptosis, inhibits DNA synthesis, downregulates Cyclin D1, and inhibits AKT/ERK/STAT3 phosphorylation. ALK/EGFR-IN-4 shows antitumor efficacy in an Osimertinib (HY-15772)-resistant EGFR triple-mutant non-small cell lung cancer xenograft model[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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ALK/EGFR-IN-4 | ALK/EGFR-IN-4 is an EGFR and ALK inhibitor (EGFRL858R/T790M/C797S (IC50 1.76 nM), EGFRL858R/T790M (2.97 nM), wild-type EGFR (59.35 nM) and ALK (1.95 nM)). ALK/EGFR-IN-4 induces G0/G1 phase arrest and Apoptosis, inhibits DNA synthesis, downregulates Cyclin D1, and inhibits AKT/ERK/STAT3 phosphorylation. ALK/EGFR-IN-4 shows antitumor efficacy in an Osimertinib (HY-15772)-resistant EGFR triple-mutant non-small cell lung cancer xenograft model. | |||||||||||||||||||||
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