3083133-71-2
3083133-71-2
Chemical Structure
FL47
- CAS No.: 3083133-71-2
- Formula:C27H37ClN4O4
- Molecular Weight:517.06
InChIKey: HBJMCYIISMZVEH-PUQOJIAISA-N
SMILES: OC1=CC(NC([C@@]2(C3)C[C@@H]4C[C@H]3C[C@](C(NCCCN5CCN(C(CCl)=O)CC5)=O)(C2)C4)=O)=CC=C1
Biological Activity: FL47 is a FEM1B modulator with an IC50 of 0.96 μM against human FEM1B. FL47 binds to FEM1B via a dual-site interaction, forming non-covalent interactions at site A while covalently modifying Cys186 at site C. FL47 stabilizes FNIP1 in a FEM1B-dependent manner in cells. FL47 can be used in studies related to root-knot nematode infections[1][2][3].
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FL47 | FL47 is a FEM1B modulator with an IC50 of 0.96 μM against human FEM1B. FL47 binds to FEM1B via a dual-site interaction, forming non-covalent interactions at site A while covalently modifying Cys186 at site C. FL47 stabilizes FNIP1 in a FEM1B-dependent manner in cells. FL47 can be used in studies related to root-knot nematode infections. | |||||||||||||||||||||
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References
- [1]. Xu L, et al. Structure-Guided Discovery of Novel Dual-Site FEM1B Ligands and Assessment of Their Use in Targeted Protein Degradation. Journal of medicinal chemistry. 2026 Jul 15. [Content Brief]
- [2]. Regmi H, et al. Integrated management of root‑knot nematode (Meloidogyne spp.) in Florida tomatoes combining host resistance and nematicides. Crop Protection. 2020 Aug;134:105170.
- [3]. ia L, et al. Expression patterns of volatile compounds during 'FL 47' tomato ripening and their response to exogenous methyl salicylate (MeSA) fumigation. Postharvest Biology and Technology. 2023;203:112414.
