3084918-70-4
Chemical Structure
KRAS-IN-54
- CAS No.: 3084918-70-4
- Formula:C60H78F5N11O7S
- Molecular Weight:1192.39
InChIKey: NWYQXVRUBMRBFV-GSIAOWQVSA-N
SMILES: CO[C@H](C1=[C@@](C=C(C=N1)N2CCN(CC2)C)[C@@]3=C4CC(C)(COC([C@@H]5CCCN(C([C@H](CC6=NC(C7=CC4=C(N3CC(F)(F)F)C=C7F)=CS6)NC([C@@H](N(C(C8(F)CCN(C([C@H]9N(C)[C@@H]9C%10CC%10)=O)CC8)=O)C)C%11CCCC%11)=O)=O)N5)=O)C)C
Biological Activity: KRAS-IN-54 is a macrocyclic KRAS inhibitor. KRAS-IN-54 exhibits activity against cell viability and pERK inhibition in cells with KRASG12D and KRASG13D mutations. KRAS-IN-54 can be used in the research of KRAS-mutant cancers, including pancreatic adenocarcinoma, colorectal cancer, non-small cell lung cancer, esophageal cancer, gallbladder cancer, melanoma, ovarian cancer and endometrial cancer[1].
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KRAS-IN-54 | KRAS-IN-54 is a macrocyclic KRAS inhibitor. KRAS-IN-54 exhibits activity against cell viability and pERK inhibition in cells with KRASG12D and KRASG13D mutations. KRAS-IN-54 can be used in the research of KRAS-mutant cancers, including pancreatic adenocarcinoma, colorectal cancer, non-small cell lung cancer, esophageal cancer, gallbladder cancer, melanoma, ovarian cancer and endometrial cancer. | |||||||||||||||||||||
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