3085154-16-8
Chemical Structure
TrxR2-IN-1
- CAS No.: 3085154-16-8
- Formula:C50H60BrO3P
- Molecular Weight:819.89
InChIKey: QYHXAGJLOQRBKX-BWRSMHPSSA-M
SMILES: C[C@]12[C@@]3([H])[C@@]4(CC[C@]1([H])[C@@](C)(CCC2)C(OCC5=CC=CC=C5)=O)C[C@](C(C4)=C)(CC3)OCCCCC[P+](C6=CC=CC=C6)(C7=CC=CC=C7)C8=CC=CC=C8.[Br-]
Biological Activity: TrxR2-IN-1 is a thioredoxin reductase 2 (TrxR2) inhibitor with an IC50 value of 0.83 μM. TrxR2-IN-1 accumulates in mitochondria, impairs mitochondrial function and membrane potential, increases reactive oxygen species (ROS) levels, activates ASK1-mediated caspase-dependent apoptosis (apoptosis), induces G2/M cell cycle arrest, and inhibits cancer cell migration. TrxR2-IN-1 can be used in the research of hepatocellular carcinoma[1].
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TrxR2-IN-1 | TrxR2-IN-1 is a thioredoxin reductase 2 (TrxR2) inhibitor with an IC50 value of 0.83 μM. TrxR2-IN-1 accumulates in mitochondria, impairs mitochondrial function and membrane potential, increases reactive oxygen species (ROS) levels, activates ASK1-mediated caspase-dependent apoptosis (apoptosis), induces G2/M cell cycle arrest, and inhibits cancer cell migration. TrxR2-IN-1 can be used in the research of hepatocellular carcinoma. | |||||||||||||||||||||
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