3085413-22-2
Chemical Structure
IDO1/TDO-IN-8
- CAS No.: 3085413-22-2
- Formula:C17H14N2S
- Molecular Weight:278.37
InChIKey: AMWAVCBKGXAMKK-UHFFFAOYSA-N
SMILES: CC1=CC(C2=NC=CC3=C2NC4=C3C=CC=C4)=C(C)S1
Biological Activity: IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor that can penetrate the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. IDO1/TDO-IN-8 reduces the kynurenine/tryptophan ratio by regulating the kynurenine pathway of tryptophan metabolism. IDO1/TDO-IN-8 has a neuroprotective effect and can alleviate motor dysfunction and improve depressive behavior. IDO1/TDO-IN-8 can be used in the study of Parkinson's disease combined with depression[1].
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IDO1/TDO-IN-8 | IDO1/TDO-IN-8 (Compound CZ-17) is a dual IDO1 and TDO inhibitor that can penetrate the blood-brain barrier, with EC50 values of 0.33 μM and 1.78 μM, respectively. IDO1/TDO-IN-8 reduces the kynurenine/tryptophan ratio by regulating the kynurenine pathway of tryptophan metabolism. IDO1/TDO-IN-8 has a neuroprotective effect and can alleviate motor dysfunction and improve depressive behavior. IDO1/TDO-IN-8 can be used in the study of Parkinson's disease combined with depression. | |||||||||||||||||||||
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