3088042-00-3
3088042-00-3
Chemical Structure
EGFR-IN-209
- CAS No.: 3088042-00-3
- Formula:C21H25N5O
- Molecular Weight:363.46
InChIKey: WZARRICMYMAJKS-UHFFFAOYSA-N
SMILES: OC1=CC=CC=C1C2=NC(NCCN3CCN(C)CC3)=C4C=CC=CC4=N2
Biological Activity: EGFR-IN-209 (Compound 6g) is an orally active, selective EGFRDel19/T790M/C797S inhibitor with an IC50 of 0.056 μM. EGFR-IN-209 blocks the phosphorylation of EGFR and its downstream effector molecules (pMAPK, pAKT). EGFR-IN-209 induces Apoptosis. EGFR-IN-209 exhibits antitumor activity against Osimertinib (HY-15772)-resistant non-small cell lung cancer. EGFR-IN-209 can be used in research related to non-small cell lung cancer[1].
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EGFR-IN-209 | EGFR-IN-209 (Compound 6g) is an orally active, selective EGFRDel19/T790M/C797S inhibitor with an IC50 of 0.056 μM. EGFR-IN-209 blocks the phosphorylation of EGFR and its downstream effector molecules (pMAPK, pAKT). EGFR-IN-209 induces Apoptosis. EGFR-IN-209 exhibits antitumor activity against Osimertinib (HY-15772)-resistant non-small cell lung cancer. EGFR-IN-209 can be used in research related to non-small cell lung cancer. | |||||||||||||||||||||
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