3091379-82-4
3091379-82-4
Chemical Structure
ZJY-54
- CAS No.: 3091379-82-4
- Formula:C29H30D3N7O2
- Molecular Weight:514.64
InChIKey: XBVQISMCXPSCBG-UAJIRTNRSA-N
SMILES: COC1=C(C=C(C(N2C[C@@H](CC2)N(C)C)=C1)NC(C=C)=O)NC3=NC(C4=CN(C([2H])([2H])[2H])C5=CC=CC=C54)=CC=N3
Biological Activity: ZJY-54 is an orally active dual-target inhibitor of EGFR/LSD1, with IC50 values of 3.8 nM and 0.6 μM, respectively. ZJY-54 can inhibit the proliferation of non-small cell lung cancer cells, induce the accumulation of H3K4me2 and H3K9me2, and inhibit the phosphorylation of the EGFR signaling pathway. ZJY-54 has anti-tumor activity[1].
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ZJY-54 | ZJY-54 is an orally active dual-target inhibitor of EGFR/LSD1, with IC50 values of 3.8 nM and 0.6 μM, respectively. ZJY-54 can inhibit the proliferation of non-small cell lung cancer cells, induce the accumulation of H3K4me2 and H3K9me2, and inhibit the phosphorylation of the EGFR signaling pathway. ZJY-54 has anti-tumor activity. | |||||||||||||||||||||
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