3093312-81-0
Chemical Structure
PGK1-IN-1
- CAS No.: 3093312-81-0
- Formula:C22H28N6O3
- Molecular Weight:424.50
InChIKey: HVPYNCRXTJNWOP-SAZUREKKSA-N
SMILES: COC1=CC(NC(N=C(N[C@H]2CC[C@@H](CC2)O)N=C34)=C4N=CN3C5CC5)=CC(OC)=C1
Biological Activity: PGK1-IN-1 (Compound 6e) is a potent and selective PGK1 inhibitor (IC50: 33 nM). PGK1-IN-1 inhibits PGK1-mediated glycolytic metabolism and reduces glucose consumption/lactate production. PGK1-IN-1 enhances Nrf2 accumulation and HO-1 expression, and suppresses the transcription and protein levels of the inflammatory cytokines IL-1β and IL-6. PGK1-IN-1 ameliorates Dextran sulfate sodium (DSS) (HY-116282C)-induced experimental colitis in mice. PGK1-IN-1 can be used for research of inflammatory bowel disease (IBD)[1].
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PGK1-IN-1 | 99.78% | PGK1-IN-1 (Compound 6e) is a potent and selective PGK1 inhibitor (IC50: 33 nM). PGK1-IN-1 inhibits PGK1-mediated glycolytic metabolism and reduces glucose consumption/lactate production. PGK1-IN-1 enhances Nrf2 accumulation and HO-1 expression, and suppresses the transcription and protein levels of the inflammatory cytokines IL-1β and IL-6. PGK1-IN-1 ameliorates Dextran sulfate sodium (DSS) (HY-116282C)-induced experimental colitis in mice. PGK1-IN-1 can be used for research of inflammatory bowel disease (IBD). | ||||||||||||||||||||
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