3093413-94-3
Chemical Structure
PROTAC sEH degrader-3
- CAS No.: 3093413-94-3
- Formula:C46H53F3N6O14
- Molecular Weight:970.94
IUPAC Name: N-(1-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)-2-oxo-6,9,12,15-tetraoxa-3-azaheptadecan-17-yl)-4-(((1r,4r)-4-(3-(4-(trifluoromethoxy)phenyl)ureido)cyclohexyl)oxy)benzamide
InChIKey: STGMSTZSBJPAMZ-YRLQYNNYSA-N
SMILES: O=C(COC1=C(C2=O)C(C(N2C3CCC(NC3=O)=O)=O)=CC=C1)NCCOCCOCCOCCOCCNC(C4=CC=C(O[C@@H]5CC[C@H](CC5)NC(NC6=CC=C(OC(F)(F)F)C=C6)=O)C=C4)=O
Biological Activity: PROTAC sEH-degrader-3 is an sEH PROTAC degrader with an IC50 value of 5.5 nM against mouse sEH. PROTAC sEH-degrader-3 selectively degrades sEH in the cytoplasm but not in peroxisomes. PROTAC sEH-degrader-3 alleviates endoplasmic reticulum stress and acts as a cytoprotective agent. PROTAC sEH-degrader-3 can serve as a chemical probe for investigating the biological functions of sEH[1].
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PROTAC sEH degrader-3 | PROTAC sEH-degrader-3 is an sEH PROTAC degrader with an IC50 value of 5.5 nM against mouse sEH. PROTAC sEH-degrader-3 selectively degrades sEH in the cytoplasm but not in peroxisomes. PROTAC sEH-degrader-3 alleviates endoplasmic reticulum stress and acts as a cytoprotective agent. PROTAC sEH-degrader-3 can serve as a chemical probe for investigating the biological functions of sEH. | |||||||||||||||||||||
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