3093763-71-1
3093763-71-1
Chemical Structure
HQY1428
- CAS No.: 3093763-71-1
- Formula:C25H28ClFN6O3S
- Molecular Weight:547.04
InChIKey: RJQQRJYDGHKZNA-LJQANCHMSA-N
SMILES: O=S(C1=C(C=CC=C1)NC2=C(C=NC(N[C@@H]3CCCN(C3)C(C4=CC(F)=CC(N)=C4)=O)=N2)Cl)(C(C)C)=O
Biological Activity: HQY1428 is an orally active CDK12 inhibitor. HQY1428 inhibits DNA replication, causes G2/M arrest in SKOV3 cells, induces DNA double-strand breaks and apoptosis. HQY1428 has anti-tumor activity in the SKOV3 xenograft mouse model. HQY1428 combined with the HER2 inhibitor Lapatinib (HY-50898) in the NCI-N87 xenograft mouse model produces a synergistic therapeutic effect[1].
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HQY1428 | 99.65% | HQY1428 is an orally active CDK12 inhibitor. HQY1428 inhibits DNA replication, causes G2/M arrest in SKOV3 cells, induces DNA double-strand breaks and apoptosis. HQY1428 has anti-tumor activity in the SKOV3 xenograft mouse model. HQY1428 combined with the HER2 inhibitor Lapatinib (HY-50898) in the NCI-N87 xenograft mouse model produces a synergistic therapeutic effect. | ||||||||||||||||||||
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