3094990-88-9
Chemical Structure
ETC-501
- CAS No.: 3094990-88-9
- Formula:C26H24N6O2
- Molecular Weight:452.51
InChIKey: QMLNQDUPMCNENH-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C(C2=NC3=C(C#CC4=CC=NC(N(C)C)=C4)C=NN3C=C2)C=C1)N5CCOCC5
Biological Activity: ETC-501 is a blood-brain barrier-permeable, orally active, and selective MNK1/MNK2 inhibitor, with an IC50 of 0.033 μM against MNK1 and 0.111 μM against MNK2. ETC-501 inhibits glioblastoma cell proliferation, impairs DNA damage repair function, delays cell cycle progression, and suppresses ribosome biogenesis. ETC-501 enhances Temozolomide (HY-17364)-induced cellular senescence, attenuates the senescence-associated secretory phenotype, and increases cellular sensitivity to Navitoclax (HY-10087). ETC-501 is applicable to research related to glioblastoma[1].
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ETC-501 | 97.40% | ETC-501 is a blood-brain barrier-permeable, orally active, and selective MNK1/MNK2 inhibitor, with an IC50 of 0.033 μM against MNK1 and 0.111 μM against MNK2. ETC-501 inhibits glioblastoma cell proliferation, impairs DNA damage repair function, delays cell cycle progression, and suppresses ribosome biogenesis. ETC-501 enhances Temozolomide (HY-17364)-induced cellular senescence, attenuates the senescence-associated secretory phenotype, and increases cellular sensitivity to Navitoclax (HY-10087). ETC-501 is applicable to research related to glioblastoma. | ||||||||||||||||||||
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