3096878-87-1
Chemical Structure
Ferroptosis-IN-22
- CAS No.: 3096878-87-1
- Formula:C27H23NO2
- Molecular Weight:393.48
IUPAC Name: 6-(tert-butyl)-2,4-diphenylbenzofuro[2,3-b]pyridin-7-ol
InChIKey: KFYPZJHJADJHFW-UHFFFAOYSA-N
SMILES: CC(C)(C1=C(O)C=C2C(C(C(C3=CC=CC=C3)=C4)=C(O2)N=C4C5=CC=CC=C5)=C1)C
Biological Activity: Ferroptosis-IN-22 is a selective ferroptosis inhibitor by targeting NCOA4 and disrupting its interaction with ferritin with an EC50 of 520 nM and a Kd of 0.78 μM. Ferroptosis-IN-22 has a strong inhibitory activity against ferroptosis induced by multiple ferroptosis inducers (RSL3 (HY-100218A), Erastin (HY-15763), ML210 (HY-100003), FIN56 (HY-103087)), but does not inhibit necrosis induced by H2O2 or apoptosis induced by STS (HY-15141). Ferroptosis-IN-22 effectively ameliorates Concanavalin A (HY-P2149)-induced acute liver injury. Ferroptosis-IN-22 can be used for the study of ferroptosis-related diseases[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ferroptosis-IN-22 | 99.95% | Ferroptosis-IN-22 is a selective ferroptosis inhibitor by targeting NCOA4 and disrupting its interaction with ferritin with an EC50 of 520 nM and a Kd of 0.78 μM. Ferroptosis-IN-22 has a strong inhibitory activity against ferroptosis induced by multiple ferroptosis inducers (RSL3 (HY-100218A), Erastin (HY-15763), ML210 (HY-100003), FIN56 (HY-103087)), but does not inhibit necrosis induced by H2O2 or apoptosis induced by STS (HY-15141). Ferroptosis-IN-22 effectively ameliorates Concanavalin A (HY-P2149)-induced acute liver injury. Ferroptosis-IN-22 can be used for the study of ferroptosis-related diseases. | ||||||||||||||||||||
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