3097045-01-4
Chemical Structure
NAMPT/PD-1/PD-L1-IN-1
- CAS No.: 3097045-01-4
- Formula:C36H35ClN10O
- Molecular Weight:659.18
InChIKey: QBGTXDQTLYZIJA-UHFFFAOYSA-N
SMILES: ClC1=C(C=CC=C1OCCCN2CCCC2)C3=CC=CC4=C3CCN4C5=NC=NC6=C5N=CC(CN/C(NC7=CC=NC=C7)=N\C#N)=C6
Biological Activity: NAMPT/PD-1/PD-L1-IN-1 is a potent the PD-1/PD-L1 interaction and NAMPT dual inhibitor with IC50s of 7.5 nM and 18.8 nM, respectively. NAMPT/PD-1/PD-L1-IN-1 enhances T cell-mediated tumor cell killing, promotes T cell proliferation and CD8+ T cell proportion and depletes intracellular NAD+ biosynthesis. NAMPT/PD-1/PD-L1-IN-1 suppresses tumor progression in a mouse LLC xenograft model by disrupting tumor metabolism and activating the tumor immune microenvironment. NAMPT/PD-1/PD-L1-IN-1 can be used in research on tumor immunotherapy for non-small cell lung cancer[1].
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NAMPT/PD-1/PD-L1-IN-1 | NAMPT/PD-1/PD-L1-IN-1 is a potent the PD-1/PD-L1 interaction and NAMPT dual inhibitor with IC50s of 7.5 nM and 18.8 nM, respectively. NAMPT/PD-1/PD-L1-IN-1 enhances T cell-mediated tumor cell killing, promotes T cell proliferation and CD8+ T cell proportion and depletes intracellular NAD+ biosynthesis. NAMPT/PD-1/PD-L1-IN-1 suppresses tumor progression in a mouse LLC xenograft model by disrupting tumor metabolism and activating the tumor immune microenvironment. NAMPT/PD-1/PD-L1-IN-1 can be used in research on tumor immunotherapy for non-small cell lung cancer. | |||||||||||||||||||||
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