3098437-66-9
Chemical Structure
VCP/p97 IN-3
- CAS No.: 3098437-66-9
- Formula:C31H32F2N6O3S
- Molecular Weight:606.69
IUPAC Name: (R)-3-(3-((5-(cyclohex-2-en-1-ylthio)-4-(pyridin-3-yl)-4H-1,2,4-triazol-3-yl)methoxy)-2,5-difluorophenyl)prop-2-yn-1-yl (2-methyl-2-azaspiro[3.3]heptan-6-yl)carbamate
InChIKey: MLBQISUJPMSXLG-DEOSSOPVSA-N
SMILES: O=C(OCC#CC1=CC(F)=C(OCC2=NN=C(S[C@H]3C=CCCC3)N2C4=CC=CN=C4)C=C1F)NC(C5)CC65CN(C)C6
Biological Activity: VCP/p97 IN-3 is a VCP/p97 allosteric inhibitor. VCP/p97 IN-3 shows the inhibitory activity against the VCP proteins with an IC50 of 9 nM and the mutant VCP proteins with IC50 of 12 nM (N660K) and 19 nM (V474A/D649A). VCP/p97 IN-3 increases K48-linked ubiquitination and the level of cleaved caspase-3. VCP/p97 IN-3 activates ER-stress and the UPR. VCP/p97 IN-3 inhibits tumor growth in RPMI-8226 cell subcutaneous xenograft mouse models. VCP/p97 IN-3 can be used for the study of multiple myeloma[1].
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VCP/p97 IN-3 | VCP/p97 IN-3 is a VCP/p97 allosteric inhibitor. VCP/p97 IN-3 shows the inhibitory activity against the VCP proteins with an IC50 of 9 nM and the mutant VCP proteins with IC50 of 12 nM (N660K) and 19 nM (V474A/D649A). VCP/p97 IN-3 increases K48-linked ubiquitination and the level of cleaved caspase-3. VCP/p97 IN-3 activates ER-stress and the UPR. VCP/p97 IN-3 inhibits tumor growth in RPMI-8226 cell subcutaneous xenograft mouse models. VCP/p97 IN-3 can be used for the study of multiple myeloma. | |||||||||||||||||||||
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