3100238-91-0
3100238-91-0
Chemical Structure
YL246
- CAS No.: 3100238-91-0
- Formula:C36H47N7O5
- Molecular Weight:657.80
InChIKey: VHIRMXCQAOSEHJ-UHFFFAOYSA-N
SMILES: O=C(NNCCCCCC)C(C=C1)=CC=C1N(CC2)CCN2CC3CCN(C4=C(C5=O)C(C(N5C(C(N6)=O)CCC6=O)=O)=CC=C4)CC3
Biological Activity: YL246 is a selective, CRBN-recruiting HDAC8 PROTAC degrader, DC50 = 3.75 nM. YL246 induces CRBN- and proteasome-dependent degradation of zinc-dependent HDAC8 through CRBN ligand-mediated ubiquitination. YL246 has poor metabolic stability. YL246 can be used for HDAC8-mediated cancer-related research, such as breast cancer[1].
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YL246 | YL246 is a selective, CRBN-recruiting HDAC8 PROTAC degrader, DC50 = 3.75 nM. YL246 induces CRBN- and proteasome-dependent degradation of zinc-dependent HDAC8 through CRBN ligand-mediated ubiquitination. YL246 has poor metabolic stability. YL246 can be used for HDAC8-mediated cancer-related research, such as breast cancer. | |||||||||||||||||||||
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